Study links immune responses to intestinal microbes with rheumatoid arthritis
In patients with rheumatoid arthritis (RA), self-reactive T cell responses cause inflammation and progressive damage to synovial joints. Although genetic risk factors for RA have been identified,...
View ArticleResearchers make significant progress in engineering digestive system tissues
Researchers at Wake Forest Institute for Regenerative Medicine have reached important milestones in their quest to engineer replacement tissue in the lab to treat digestive system conditions - from...
View Article'Fusion genes' drive formation and growth of colorectal cancer
Genetic mutations caused by rearranged chromosomes drive the development and growth of certain colorectal cancers, according to new research conducted by Weill Cornell Medicine investigators.
View ArticleTitanium dioxide nanoparticles can exacerbate colitis
Titanium dioxide, one of the most-produced nanoparticles worldwide, is being used increasingly in foodstuffs. When intestinal cells absorb titanium dioxide particles, this leads to increased...
View ArticleUsing a pig model to study chronic diseases may help minimize drug failure rate
Scientists may be able to minimize the failure rate of drugs for diseases linked to high-calorie diets, such as colon cancer and type 2 diabetes, if they test treatments using a pig model, according to...
View ArticleImmunotherapy efficacy up with Gal-1/SIT co-administration
(HealthDay)—Galectin-1 (Gal-1), allergen-specific immunotherapy (SIT) co-administration may suppress allergic responses in the intestine more than use of SIT or Gal-1 alone, according to an...
View ArticleStudy uncovers potential 'silver bullet' for preventing and treating colon...
In preclinical experiments, researchers at VCU Massey Cancer Center have uncovered a new way in which colon cancer develops, as well as a potential "silver bullet" for preventing and treating it. The...
View ArticleTeam finds link between backup immune defense, mutation seen in Crohn's disease
Genes that regulate a cellular recycling system called autophagy are commonly mutated in Crohn's disease patients, though the link between biological housekeeping and inflammatory bowel disease...
View ArticleHow dietary fiber helps the intestines maintain health
UC Davis Health researchers have discovered how by-products of the digestion of dietary fiber by gut microbes act as the right fuel to help intestinal cells maintain gut health.
View ArticleThe lining of our intestines uses an approach known to business to quickly...
Every time we swallow food, cells that line the intestines must step up their activity in a sudden and dramatic manner. According to a new study by Weizmann Institute of Science researchers, reported...
View ArticleInnate lymphoid cells play an important role in regulation of intestinal...
The intestine contains an extensive and diverse microbial biome, a population that includes potential pathogens and dietary antigens that need to be tolerated. Dysregulation of mucosal responses may...
View ArticleThe colons of patients with IBS react differently to bacteria
The intestinal barrier of patients with the gastrointestinal disease IBS allows bacteria to pass more freely than in healthy people, according to a study led by researchers at Linköping University in...
View ArticleNew technologies combined to identify specific DNA defect underlying a type...
(Medical Xpress)—A team of researchers from the Netherlands and the U.K. has developed a technique for studying inherited types of cancers using two relatively new technologies—organoid development and...
View ArticleImmune cells produce wound healing factor, could lead to new IBD treatment
Specific immune cells have the ability to produce a healing factor that can promote wound repair in the intestine, a finding that could lead to new, potential therapeutic treatments for inflammatory...
View ArticleProtein regulates vitamin A metabolic pathways, prevents inflammation
A team of researchers from Case Western Reserve University School of Medicine have discovered how uncontrolled vitamin A metabolism in the gut can cause harmful inflammation. The discovery links diet...
View ArticleNew way to prevent unfavorable intestinal microbiota
The trillions of microbes living in a mammal's intestine play an important role in the host's metabolism and immunity. The composition of microbiota is maintained by antimicrobial proteins secreted...
View ArticleAPC protein affects colon cancer immunity by preventing pre-cancerous...
Adenomatous polyposis coli (APC) is a gene whose mutations are associated with a rare, hereditary form of colorectal cancer known as familial adenomatous polyposis. Research led by scientists at the...
View ArticleGut response to fluid flow
Flow of fluids through the gut, such as milk from an infant's diet, generates a shear stress on cells lining the intestine. Ken Lau, Ph.D., and colleagues have demonstrated that microvilli –...
View ArticleResearchers produce the first draft cell atlas of the small intestine
The lining or epithelium of the gut is one of the body's most diverse and dynamic tissues, an ecosystem of cells that acts as one of the body's main interfaces with the outside world. To better...
View ArticleStem cells in intestinal lining may shed light on behavior of cancer cells
The lining of the intestines - the epithelium - does more than absorb nutrients from your lunch. It grows, shrinks, and adjusts the very makeup of its cells in response to whatever you just ate. And...
View ArticleStem cell-derived intestine model mimics innate immune responses
A stem cell-derived in vitro model displays key small intestine characteristics including innate immune responses, according to a study published November 29, 2017 in the open-access journal PLOS ONE...
View ArticleMolecule plays dual role in bowel health and disease
A molecule that controls intestinal cell growth plays a dual role maintaining gut health and promoting diseases such as cancer, says a study in eLife.
View ArticleLineage tracing in the gut
Scientists are finding that they can understand organ function (and dysfunction in the case of disease) better if they know where the cells that make up these organs came from.
View ArticleCD4 T cells, xenobiotic transporters, and metabolites in inflammatory bowel...
The immune system counters pathogenic microbes and toxins in the environment. The system comprises innate (non-specific) and adaptive (acquired) immunity. When innate immune cells recognize pathogens,...
View ArticleOxysterols guide gut immune cells and are involved in inflammatory bowel disease
Researchers at Karolinska Institutet in Sweden report that cholesterol metabolites cause specific immune cells in the large intestine to move, which lies behind the formation of the immune system's...
View ArticleUnexpected findings prompt re-evaluation of how the intestine repairs itself
Researchers at Baylor College of Medicine, Johns Hopkins University School of Medicine and the University of California, San Francisco have gained new insights into how the small intestine, one of the...
View ArticleStudy could explain link between high-cholesterol diet and colon cancer
New UCLA research could help explain the link between a high-cholesterol diet and an elevated risk for colon cancer.
View ArticleCellular models of fetal intestinal tissue may help combat deadly neonatal...
Cellular models of fetal and adult intestinal tissues generated by investigators from the Mucosal Immunology and Biology Research Center (MIBRC) at MassGeneral Hospital for Children (MGHfC) have...
View ArticleA possible way to protect intestinal walls from damage due to chemotherapy
A team of researchers at the University of Pittsburgh has found a possible way to protect cells in the intestines when subjected to chemotherapy. In their paper published in Science Translational...
View ArticleGut bacteria: It can be good, and bad, for health
The human microbiome—the trillions of tiny bacteria that live in and on our bodies—is emerging as an increasingly important player in health and wellness. But, our co-existence with these organisms is...
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